Table 1 Apparent potency values (pEC50) and pseudo-Hill slopes (nH) of norepinephrine (NE), dopamine (DA) and epinephrine (EP) in the absence (−) or presence of 1 µM nisoxetine on JumpIn-NET cells treated with vehicle (−dox) or doxycycline (+dox) in TRACT assays.
Substrate | Pretreatment | pEC50 ± SEMa,b | Slope (nH) ± SEMa,b | n | |
---|---|---|---|---|---|
NE | −dox | – | 6.4 ± 0.1 | 0.8 ± 0.1 | 7 |
−dox | Nisoxetine | 6.5 ± 0.0 | 0.9 ± 0.1 | 5 | |
+dox | – | 5.2 ± 0.1*** | 2.1 ± 0.2*** | 8 | |
+dox | Nisoxetine | 6.3 ± 0.1d | 0.9 ± 0.1d | 6 | |
DA | −dox | – | 5.1 ± 0.1 | 0.8 ± 0.1 | 3 |
+dox | – | 4.7 ± 0.0** | 1.5 ± 0.1** | 7 | |
+dox | Nisoxetine | 4.4 ± 0.1c | 0.6 ± 0.0d | 4 | |
EP | −dox | – | 6.4 ± 0.2 | 0.6 ± 0.0 | 3 |
+dox | – | 5.4 ± 0.1*** | 0.8 ± 0.1 | 6 | |
+dox | Nisoxetine | 6.3 ± 0.1d | 0.6 ± 0.1 | 3 |