Table 2 Inhibitory potency (pIC50) values of NET inhibitors determined in the TRACT assay and fluorescent substrate uptake assay.
Inhibitor | pIC50a | |||
---|---|---|---|---|
TRACT assayb | n | Fluorescent substrate uptake assayc | n | |
Amitriptyline | 6.7 ± 0.1 | 4 | 7.2 ± 0.1 | 5 |
Atomoxetine | 7.7 ± 0.1 | 4 | 8.6 ± 0.0 | 3 |
Benztropine | 6.5 ± 0.1 | 3 | 6.1 ± 0.1 | 3 |
Bupropion | 4.9 ± 0.1 | 3 | 5.5 ± 0.0 | 3 |
Cocaine | 6.2 ± 0.1 | 4 | n.d.d | |
Desipramine | 8.2 ± 0.1 | 3 | 8.6 ± 0.1 | 5 |
GBR12909 | 6.1 ± 0.2 | 3 | 6.0 ± 0.1 | 3 |
Maprotiline | 7.3 ± 0.1 | 4 | 7.4 ± 0.1 | 3 |
Milnacipran | 7.3 ± 0.2 | 4 | 7.8 ± 0.0 | 3 |
Nisoxetine | 8.3 ± 0.1 | 7 | 8.4 ± 0.1 | 5 |
Nortriptyline | 7.4 ± 0.1 | 5 | 8.0 ± 0.1 | 5 |
Reboxetine | 8.3 ± 0.1 | 5 | 8.8 ± 0.0 | 5 |