Table 1 Baseline characteristics of study participants.
Characteristic | Healthy subjects | Patients with chronic kidney disease | |
|---|---|---|---|
Colonic dialysis | No dialysis | ||
N | 34 | 25 | 25 |
Age (year) | 52.62 ± 6.68 | 56.24 ± 11.7 | 51.08 ± 8.58 |
Male | 16 (47.1) | 12 (48) | 13(52) |
SBP (mmHg) | 119.63 ± 18.69 | 138.72 ± 17.37* | 136.04 ± 17.92# |
DBP (mmHg) | 77.50 ± 12.00 | 81.96 ± 9.01 | 79.32 ± 10.08 |
CKD stage | |||
3–4 (eGFR 15–59) | 0 | 10 | 13 |
5 (eGFR < 15) | 0 | 15 | 12 |
Primary disease | |||
CGN | 0 | 9 | 16 |
DM | 0 | 5 | 6 |
HT | 0 | 7 | 0 |
SLE | 0 | 1 | 0 |
AP | 0 | 1 | 0 |
DPKD | 0 | 0 | 1 |
Other | 0 | 2 | 2 |
Colonic dialysis duration (year) | – | 3.26 ± 2.52(0.6–8.5) | – |
Colonic dialysis frequency (times per week) | – | 3.33 ± 1.39(1–7) | – |
Laboratory parameters | |||
Hb (g/L) | 141.97 ± 14.35 | 107.75 ± 20.87* | 96.92 ± 25.50# |
ALB(g/L) | 46.06 ± 2.50 | 39.67 ± 5.59* | 38.94 ± 8.00# |
LDL (mmol/L) | 3.29 ± 0.69 | 3.00 ± 0.76 | 3.16 ± 0.77 |
TG (mmol/L) | 1.57 ± 0.90 | 2.30 ± 1.38* | 2.19 ± 1.45# |
TC (mmol/L) | 5.27 ± 0.90 | 4.74 ± 1.18 | 5.06 ± 1.03 |
Glu (mmol/L) | 5.98 ± 1.86 | 5.46 ± 1.29 | 6.36 ± 3.61 |
Urea (mmol/L) | 5.29 ± 1.32 | 17.11 ± 6.93 | 16.37 ± 6.74 |
UA (mmol/L) | 334.01 ± 80.22 | 431.18 ± 104.95* | 443.14 ± 103.85# |
K (mmol/L) | – | 4.52 ± 0.60 | 4.64 ± 0.71 |
Ca (mmol/L) | – | 2.21 ± 0.15 | 2.20 ± 0.19 |
P (mmol/L) | – | 1.41 ± 0.30 | 1.46 ± 0.50 |
Mg (mmol/L) | – | 0.86 ± 0.15 | 0.84 ± 0.10 |
Qualitative determination of urinary protein | |||
Negative | 30 | 1 | 1 |
Microscale | 3 | 3 | 0 |
Positive | 1 | 21 | 24 |
Medications at baseline | |||
Calcium channel-blockers | – | 17 | 11 |
ACE inhibitors/ARBs | – | 8 | 9 |
Beta-blockers | – | 10 | 7 |
Diuretics | – | 2 | 2 |
Iron agents | – | 3 | 5 |
Phosphate binders | – | 0 | 0 |
EPO | – | 5 | 7 |
Anticoagulants | – | 7 | 6 |
Lipid-lowering drugs | – | 6 | 5 |
Antidiabetic drugs | – | 4 | 4 |
Other BP-lowering drugs | – | 6 | 1 |