Figure 1
From: Dendritic spines are lost in clusters in Alzheimer’s disease
CA1 pyramidal neurons with and without tau pathology. Confocal microscopy pictures obtained after combining the channels acquired separately for LY (green) and phospho-tau AT8 (red), showing (A–F) neurons and (G–J) their basal dendrites, (A–C,G–H) with a soma free of phospho-tau AT8 (SomaTau-) and (D–F,I–J) with phospho-tau AT8 in an intermediate stage of neurofibrillary pathology (SomaTau +). The position of the soma is indicated with an arrow in (B,C) and (E,F). (K) High resolution image of a dendritic segment indicated with a bracket in J. (L) The same representative image as in (K) showing all the spines along the dendrite marked with a white line and pink dots for their insertion points. (M) 3D spatial distribution of all spines insertion points. Scale bar shown in (M) indicates 12 µm in (A–F), 5 µm in (G–J), and 3 µm in (K–M).
