Figure 3
From: Dendritic spines are lost in clusters in Alzheimer’s disease
Spine organization into communities. (A) Schematic representation of a dendrite with spines that can be clearly separated into three distinct communities and their corresponding adjacency matrix showing the blocks of connections that correspond to each community. (B) We also show an example of a community structure for one of the dendrites assessed in the current study with seven communities. The community structure is assessed using the average distance between spines that belong to each community (characteristic community extension, CCE) and the number of spines in each community. Ypos and Xpos, μm. (C,E) We show the values obtained in these two measures for each SomaTau + (red, n = 6) and SomaTau- (green, n = 5) dendrite, which are computed by calculating the community structure over 100 trials. In addition, we include (D) boxplots with the group averages for the CCE and (F) the average community size or number of spines for each community, which are both smaller in SomaTau + compared to SomaTau- dendrites. The bottom and the top edges of the boxplots denote the 25th and 75th percentiles of the data, respectively. The whiskers extend to the largest and smallest data points. The results are similar after excluding the outlier.
