Figure 1 | Scientific Reports

Figure 1

From: Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes

Figure 1

(a) Representative images of rat lungs after procurement. (b) Heparanase activity was detected in tissue after procurement following 1 h of warm ischemia. (c) Ultrastructural images of the endothelial glycocalyx (eGC) from lung grafts after 1 h of warm ischemia obtained using transmission electron microscopy. The labeled glycocalyx appears as the darker cell surface layer; black arrow indicates glycocalyx desquamated from the surface of an endothelial cell. *p < 0.05, **p < 0.01. NL native lungs, Ctrl control lungs with eGC damage induced by 1 h of ischemia, Hep lungs with eGC preserved by heparin administration prior to 1 h of ischemia, NAH lungs with intact eGC preserved by N-acetyl heparin administration prior to 1 h of ischemia.

Back to article page