Figure 2
From: An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants
Molecular effects of T27Y and H34A ACE2 mutations predicted by MD simulation. (a) Spike (S) occurs as a trimer on the viral surface (orange projections), with the receptor binding domain (RBD) being on the outermost surface. The interface between S RBD and ACE2 is within the dashed box. Simulation models are shown for (b) ACE2(T27Y)-, (c) ACE2(H34A)-, and (d) ACE2(T27Y/H34A)-S RBD interactions. S RBD residues are labeled in the yellow boxes and ACE2 residues in blue boxes.
