Table 6 All protein groups which were more than 4 times as abundant in resistant K. pneumoniae isolates compared to susceptible K. pneumoniae isolates.
Protein | Most correlated to resistance to | P-value | Fold change | Curated in CARD |
---|---|---|---|---|
Aminoglycoside O-phosphotransferase APH(3″)-Ib | 3rd gen cephalosporins | < 0.001 | 5.70 | Yes |
Class A extended-spectrum beta-lactamase CTX-M-15 | 3rd gen cephalosporins | < 0.001 | 41.51 | Yes |
Heat shock survival AAA family ATPase ClpK | 3rd gen cephalosporins | 0.002 | 4.00 | No |
Subclass B1 metallo-beta-lactamase NDM-1 | Meropenem | < 0.001 | 7.29 | Yes |
Class A extended-spectrum beta-lactamase SHV-5 | Meropenem | < 0.001 | 8.74 | Yes |
Type A-1 chloramphenicol O-acetyltransferase | Meropenem | < 0.001 | 9.69 | Yes |
Aminoglycoside O-phosphotransferase APH(3′)-Ia | Meropenem | < 0.001 | 10.97 | Yes |
Carbapenem-hydrolyzing class A beta-lactamase KPC-2 | Meropenem | < 0.001 | 20.03 | Yes |
Ribonuclease E | Meropenem | < 0.001 | 4.75 | No |
Type I restriction endonuclease subunit R | Meropenem | < 0.001 | 4.70 | No |
Porin (not otherwise specified) | Meropenem | < 0.001 | 4.07 | No |
Trigger factor | Meropenem | < 0.001 | 6.31 | No |
Hypothetical protein | Meropenem | < 0.001 | 4.72 | No |
Outer membrane protein assembly factor BamE | Meropenem | < 0.001 | 4.19 | No |
C-Lysozyme inhibitor | Meropenem | < 0.001 | 4.86 | No |
Aldo/keto reductase family oxidoreductase | Meropenem | < 0.001 | 4.26 | No |
SAM-dependent DNA methyltransferase | Meropenem | < 0.001 | 4.73 | No |
DUF305 domain-containing protein | Meropenem | < 0.001 | 12.18 | No |
Aminoglycoside N-acetyltransferase AAC(3)-IIa | Aminoglycosides | < 0.001 | 6.05 | Yes |
Fluoroquinolone-acetylating aminoglycoside 6′-N-acetyltransferase AAC(6′)-Ib-cr5 | Aminoglycosides | < 0.001 | 32.97 | Yes |
Multidrug efflux RND transporter periplasmic adaptor subunit OqxA | Ciprofloxacin | < 0.001 | 5.04 | Yes |
Class A broad-spectrum beta-lactamase TEM-1 | Ciprofloxacin | < 0.001 | 9.10 | Yes |
LPS assembly lipoprotein LptE | Ciprofloxacin | < 0.001 | 4.12 | No |