Table 6 All protein groups which were more than 4 times as abundant in resistant K. pneumoniae isolates compared to susceptible K. pneumoniae isolates.

From: Exploring antimicrobial resistance to beta-lactams, aminoglycosides and fluoroquinolones in E. coli and K. pneumoniae using proteogenomics

Protein

Most correlated to resistance to

P-value

Fold change

Curated in CARD

Aminoglycoside O-phosphotransferase APH(3″)-Ib

3rd gen cephalosporins

< 0.001

5.70

Yes

Class A extended-spectrum beta-lactamase CTX-M-15

3rd gen cephalosporins

< 0.001

41.51

Yes

Heat shock survival AAA family ATPase ClpK

3rd gen cephalosporins

0.002

4.00

No

Subclass B1 metallo-beta-lactamase NDM-1

Meropenem

< 0.001

7.29

Yes

Class A extended-spectrum beta-lactamase SHV-5

Meropenem

< 0.001

8.74

Yes

Type A-1 chloramphenicol O-acetyltransferase

Meropenem

< 0.001

9.69

Yes

Aminoglycoside O-phosphotransferase APH(3′)-Ia

Meropenem

< 0.001

10.97

Yes

Carbapenem-hydrolyzing class A beta-lactamase KPC-2

Meropenem

< 0.001

20.03

Yes

Ribonuclease E

Meropenem

< 0.001

4.75

No

Type I restriction endonuclease subunit R

Meropenem

< 0.001

4.70

No

Porin (not otherwise specified)

Meropenem

< 0.001

4.07

No

Trigger factor

Meropenem

< 0.001

6.31

No

Hypothetical protein

Meropenem

< 0.001

4.72

No

Outer membrane protein assembly factor BamE

Meropenem

< 0.001

4.19

No

C-Lysozyme inhibitor

Meropenem

< 0.001

4.86

No

Aldo/keto reductase family oxidoreductase

Meropenem

< 0.001

4.26

No

SAM-dependent DNA methyltransferase

Meropenem

< 0.001

4.73

No

DUF305 domain-containing protein

Meropenem

< 0.001

12.18

No

Aminoglycoside N-acetyltransferase AAC(3)-IIa

Aminoglycosides

< 0.001

6.05

Yes

Fluoroquinolone-acetylating aminoglycoside 6′-N-acetyltransferase AAC(6′)-Ib-cr5

Aminoglycosides

< 0.001

32.97

Yes

Multidrug efflux RND transporter periplasmic adaptor subunit OqxA

Ciprofloxacin

< 0.001

5.04

Yes

Class A broad-spectrum beta-lactamase TEM-1

Ciprofloxacin

< 0.001

9.10

Yes

LPS assembly lipoprotein LptE

Ciprofloxacin

< 0.001

4.12

No