Figure 4 | Scientific Reports

Figure 4

From: Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation

Figure 4

p21 levels influence the numbers of p-IKKα/β-, MMP-3- and MMP-13-positive cells in the CAIA mouse model. (a,d,g) Cartilage and (b,e) synovial tissue samples were collected from the knees of mice after antibody cocktail administration. (a,b,d,e,g) p21+/+ mice and p21−/− mice as control, on days 7, 14, and 28. (c) The percentage of p-IKKα/β-stained cells (number of positive cells/total number of cells) with 95% CI. (f) The percentage of MMP-3-stained cells with 95% CI. (h) The percentage of MMP-13-stained cells with 95% CI. The sections were counterstained with hematoxylin. (c,f,h), four mice were analyzed from each group. Two-way analysis of variance and Tukey’s post hoc test for multiple comparisons of paired samples were used. CI confidence interval, IKK IκB kinase complex, CAIA collagen antibody-induced arthritis, p21 cyclin-dependent kinase inhibitor 1.

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