Table 4 Correlation of cerebrospinal fluid (CSF) and plasma soluble triggering receptor expressed on myeloid cells 2 (sTREM2) with Alzheimer’s disease (AD) biomarkers in the amyloid-negative group (N=54).

From: The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease

 

CSF sTREM2

Plasma sTREM2

R

P-value

R

P-value

CSF

Aβ42

0.204

0.159

–0.041

0.779

P-tau S199

0.301

0.038

–0.142

0.335

T-tau

0.425

0.003

–0.126

0.394

Aβ42/P-tau S199

– 0.178

0.225

0.115

0.438

NfL

0.183

0.208

0.196

0.177

Plasma

NfL

–0.083

0.572

0.436

0.002

NRGN

–0.109

0.465

– 0.246

0.095

Telomere

–0.175

0.230

– 0.312

0.029

Age

–0.140

0.338

0.430

0.002

  1. Linear regression analyses were used to demonstrate a correlation between biomarkers.
  2. NfL neurofilament light chain, NRGN neurogranin.