Figure 3
Behavior and cognition assessed with the OFT, MWM and MBT. Mean walking velocity (A) and total distance walked (B) during the OFT. No differences between the experimental groups were detected. Spatial learning assessed with the MWM in a 4-day acquisition phase. All groups showed a learning curve, but no differences between the groups were observed (C). The latency to go to the former platform location in the probe phase of the MWM (D), and the mean swimming velocity (E) and total swimming distance (F) were not affected by the antibiotics assessed. Buried marbles (i.e., more than two-thirds of its surface area) were scored by 3 task scorers (G). The scores for each mouse were averaged for all scorers. Mice that were administered chloramphenicol buried more marbles than control mice (p = 0.019). CAP, chloramphenicol. N = 10 per group. Data are presented as mean ± SEM.
