Table 3 Logistic regression analyses of detailed histopathological characteristics associated with peritumoral edema.

From: Peritumoral edema in breast cancer at preoperative MRI: an interpretative study with histopathological review toward understanding tumor microenvironment

Characteristics

Unadjusted

Adjusted*

Odds ratio1

P value1

Odds ratio2

P value2

Lymphovascular invasion

2.2 (1.4, 3.4)

< 0.001

2.9 (1.3. 6.4)

0.009

Vessel ectasia

4.5 (2.2, 9.3)

< 0.001

3.3 (1.2, 8.9)

0.021

Stromal fibrosis

2.2 (1.3, 3.7)

0.004

2.5 (1.1, 5.6)

0.024

Growth pattern

0.4 (0.2, 0.7)

0.001

0.4 (0.2. 0.9)

0.036

Tumor necrosis

1.4 (1.3, 1.6)

< 0.001

1.4 (1.1, 1.7)

< 0.001

Tumor budding

  

0.8 (0.4, 1.7)

0.579

Tumor infiltrating lymphocytes

  

1.0 (0.9, 1.1)

0.926

  1. *Adjusted for the clinicopathological characteristics significantly associated with peritumoral edema univariate analysis (age, T stage, N stage, histologic grade, and subtype); hormone receptor status, human epidermal growth factor receptor 2 status, and Ki-67 index were excluded due to the multicollinearity with subtype.
  2. Due to our semi-quantitative, tiered grading system (1–4 or 5) for detailed histopathological characteristics, ORs were calculated as continuous variables. Odds ratio1 and P value1 for unadjusted logistic regression analyses. Odds ratio2 and P value2 for adjusted logistic regression analyses.
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