Table 4 Interactions between smoking status and genetic predisposition on dementia risk.

Smoking status * number of APOE ε4 alleles

–

–

–

–

–

0.002

Never * zero

–

–

–

Reference

Reference

–

Previous * one

 − 0.11

(− 0.63–0.40)

 − 0.04

(− 0.21–0.14)

0.95

(0.74–1.21)

0.82

(0.66–1.03)

0.09

–

Current * one

 − 0.85

(− 1.84–0.13)

 − 0.30

(− 0.71–0.12)

0.68

(0.42–1.11)

0.54

(0.36–0.80)

0.002

–

Previous * two

2.00

(− 0.80–4.81)

0.20

(− 0.05–0.44)

1.28

(0.91–1.79)

1.00

(0.71–1.41)

0.99

–

Current * two

 − 0.93

(− 5.95–4.10)

 − 0.12

(− 0.82–0.58)

0.88

(0.43–1.81)

0.53

(0.27–1.05)

0.07

–

Smoking status * polygenic risk category

–

–

–

–

–

0.25

Never * low

–

–

–

Reference

Reference

–

Previous * middle

0.24

(− 0.08–0.56)

0.16

(− 0.07–0.39)

2.03

(0.38–10.93)

1.19

(0.87–1.63)

0.29

–

Current * middle

 − 0.05

(− 0.77–0.67)

 − 0.03

(− 0.51–0.44)

0.91

(0.26–3.24)

0.92

(0.54–1.57)

0.77

–

Previous * high

0.26

(− 0.16–0.68)

0.15

(− 0.09–0.40)

1.58

(0.60–4.16)

1.17

(0.82–1.67)

0.39

–

Current * high

0.49

(− 0.43–1.41)

0.22

(− 0.15–0.58)

1.62

(0.59–4.44)

1.17

(0.66–2.08)

0.58

–