Figure 1 | Scientific Reports

Figure 1

From: HER2-antigen-specific humoral immune response in breast cancer lymphocytes transplanted in hu-PBL hIL-4 NOG mice

Figure 1

The hu-PBL hIL-4 NOG mice reflected HD/BC T cell and B cell phenotypes. Proportions of CD4 and CD8 T cells in human PBMCs and PBMC-transplanted NOG-hIL-4-Tg in human CD45-gated fractions were compared. (A) Healthy donor (HD) (open bar: n = 39) and breast cancer patient (BC) (black bar: n = 47) PBMCs. (B) NOG-hIL-4-Tg spleens transplanted with HD (filled bar: n = 26) or BC (white bar: n = 11) PBMCs. Data are expressed as mean ± Standard Deviation of each cell subset. *p = 0.05, **p = 0.01, ***p = 0.001, ****p = 0.0001. CD4 TN Naïve CD4+ T cell, CD8 TN Naïve CD8+ T cell, CD4 TM Memory CD4+ T cell, CD8 TM memory CD8+ T cell, TR transitional, N naïve, M memory, P plasmablast; BC breast cancer; HD healthy donor; PBMCs peripheral blood mononuclear cells.

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