Figure 7
Effects of nivolumab on antibody production by human B cells. (A) Relative amount of each human antibody class in HD-transplanted (open circle; CH401MAP; n = 4, CH401MAP + NIVO; n = 3) or BC-transplanted (filled circle; CH401MAP; n = 6, CH401MAP + NIVO; n = 5) mice. HER2 3 + BC-Ms were indicated with dotted squares. *p = 0.05, **p = 0.01. (B) Anti-CH401MAP antibody concentrations in HD- or BC-transplanted mouse plasma; CH401MAP (white bar) or CH401MAP + NIVO (gray bar) groups. **p = 0.01. BC breast cancer; HD healthy donor; Ig immunoglobulin.
