Table 3 Multivariable analysis of hazard ratio (HR) with 95% confidence interval (CI) of gastric adenocarcinoma according to exposure to androgen deprivation therapy (ADT).

From: Risk of esophageal and gastric adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer

 

Total gastric adenocarcinoma

Cardia gastric adenocarcinoma

Non-cardia gastric adenocarcinoma

No

Yes

HR (95% CI) Crude

HR (95% CI) Adjusted

No

Yes

HR (95% CI) Crude

HR (95% CI) Adjusted

No

Yes

HR (95% CI) Crude

HR (95% CI) Adjusted

All men

101,565

169

  

101,684

50

  

101,615

119

  

No ADT

84,024

150

1.00 (Reference)

Ref

84,132

42

Ref

Ref

84,066

108

Ref

Ref

All ADTs

17,541

19

0.64 (0.38–1.07)

0.64 (0.37–1.09)

17,552

8

0.95 (0.42–2.16)

0.99 (0.40–2.46)

17,549

11

0.52 (0.27–1.00)

0.49 (0.24–0.98)

AA

5298

4

0.41 (0.12–1.35)

0.33 (0.08–1.39)

5300

2

0.42 (0.05–3.33)

0.42 (0.05–3.88)

5300

2

0.41 (0.09–1.74)

0.24 (0.03–1.83)

GnRH

2074

2

0.39 (0.09–1.67)

0.42 (0.10–1.86)

2076

0

–

–

2074

2

0.50 (0.11–2.19)

0.52 (0.12–2.31)

GnRH + Flare

8243

10

0.73 (0.36–1.50)

0.74 (0.36–1.53)

8249

4

1.04 (0.35–3.13)

1.01 (0.30–3.37)

8247

6

0.59 (0.23–1.52)

0.60 (0.23–1.58)

ORCH

1287

2

1.16 (0.24–5.62)

1.04 (0.21–5.12)

1288

1

–

–

1288

1

0.60 (0.07–4.91)

0.52 (0.06–4.51)

TAB

639

1

4.00 (0.25–63.95)

5.17 (0.32–84.75)

639

1

–

–

640

0

–

–

  1. Multivariable Cox proportional hazard model including marital status (not married, married, separated and widower) and educational level; low (less than 10 years), intermediate (10–12 years) and high educational level (> 12 years).
  2. AA anti-androgens, GnRH gonadotropin releasing hormone, GnRH + Flare gonadotropin releasing hormone + flare protection with AA for a limited time (usually a month), ORCH orchiectomy, TAB total androgen blockade.
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