Figure 1
From: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19
Mpro enzymology. Panel (a) shows the initial rate of substrate cleavage by Mpro at different enzyme concentrations. Data are plotted as an average of four replicates, shown as black circles with error bars representing the standard deviation; a fit of an allosteric sigmoidal model is shown as a black line. Panels (b) and (c) show a bell-shaped relationship for both the Hill-factor and Khalf obtained for Mpro-substrate kinetics at differing concentrations of Mpro, fitted results are shown as black circles, with lines between the points. Panel (d) shows a log–log plot of [Mpro] vs Vmax; circles show the fitted results.
