Figure 3
From: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19
Potent inhibitors of SARS-CoV-2 Mpro. Structures of the compounds tested against Mpro are shown to the left of the graphs. Compounds 1–3 are calpain inhibitors and 4–7 are caspase-1 inhibitors. 1 is a pyridine analogue of ABT-957 (2), 4 is the ester prodrug SDZ 224015 with 5 Caspase-1 active acid version of 4. The upper graph shows titrations of the compounds plotted against inhibition of Mpro, and the lower graph shows the same compounds against PLpro. Data are singlicate and representative of at least four repeats on separate occasions.
