Figure 6
From: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19
Flexibility induced in the active site of SARS-CoV-2 Mpro by compounds 1 and 5 from the ReFRAME library. Grey–Ligand-free Mpro (pdb 5r8t), teal–Mpro in complex with 1, orange–Mpro in complex with 5. Figure generated with PyMOL, The PyMOL Molecular Graphics System, Version 1.8.0.5 Schrödinger, LLC (https://pymol.org/2/).
