Table 2 Metabolites and pathways in plasma samples that differed between the anxiety comorbidity with ACS and ACS group.
From: Anxiety disturbs the blood plasma metabolome in acute coronary syndrome patients
Metabolites | Ionization mode | VIP | RT (min) | m/z | Fold change (A/C) | p-value | Metabolic pathway | KEGG ID |
|---|---|---|---|---|---|---|---|---|
3-Alpha-androstanediol glucuronide | ESI− | 1.06 | 24 | 467.27 | − 2.41 | 0.00 | ||
Serotonin | ESI− | 2.14 | 15.85 | 175.28 | − 2.19 | 0.00 | Tryptophan metabolism | C00780 |
3-Hydroxycapric acid | ESI− | 1.37 | 22.75 | 187.15 | − 2.02 | 0.00 | ||
25-Hydroxyvitamin D2 | ESI− | 1.87 | 22.39 | 411.33 | − 1.82 | 0.00 | ||
Androsterone sulfate | ESI− | 1.51 | 22.16 | 367.18 | − 1.80 | 0.04 | ||
5a-Tetrahydrocorticosterone | ESI− | 1.42 | 22.36 | 349.22 | − 1.54 | 0.00 | ||
5-Androstenetriol | ESI− | 3.16 | 24.27 | 305.20 | − 1.31 | 0.00 | ||
Beta-alanine | ESI− | 1.22 | 1.60 | 88.04 | − 1.13 | 0.01 | Pyrimidine metabolism | C00099 |
4-Hydroxycyclohexylcarboxylic acid | ESI− | 1.73 | 1.61 | 143.08 | − 1.12 | 0.03 | C04404 | |
Tryptophan | ESI− | 1.94 | 1.61 | 101.05 | − 1.09 | 0.03 | Tryptophan metabolism | C00078 |
Gamma-glutamylthreonine | ESI− | 4.33 | 1.61 | 123.04 | − 1.08 | 0.01 | ||
5-Hydroxydantrolene | ESI− | 3.45 | 1.63 | 164.01 | − 1.049 | 0.00 | ||
LysoPC(20:5(5Z,8Z,11Z,14Z,17Z))a | ESI− | 1.74 | 20.74 | 540.33 | 0.82 | 0.00 | Glycerophospholipid metabolism | C04230 |
Oleoylcarnitine | ESI− | 5.00 | 31.49 | 424.33 | 0.75 | 0.01 | ||
19-Hydroxyandrost-4-ene-3,17-dione | ESI− | 1.08 | 22.43 | 301.1661 | 0.73 | 0.01 | Steroid hormone biosynthesis | C05290 |
Tetrahydrocortisone | ESI− | 1.63 | 24.32 | 363.20 | 0.69 | 0.01 | ||
aLysoPC(16:0) | ESI− | 1.18 | 21.01 | 478.29 | 0.64 | 0.00 | Glycerophospholipid metabolism | C04230 |
aLysoPC(15:0) | ESI− | 1.16 | 23.02 | 480.3096 | 0.64 | 0.00 | Glycerophospholipid metabolism | C04230 |
aLysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | ESI− | 1.61 | 21.4 | 566.35 | 0.60 | 0.00 | Glycerophospholipid metabolism | C04230 |
17-Hydroxypregnenolone sulfate | ESI− | 1.38 | 23.92 | 411.21 | 0.45 | 0.00 | ||
11-Oxo-androsterone glucuronide | ESI+ | 3.79 | 9.95 | 481.26 | 0.10 | 0.02 | ||
3-Carbamoyl-2-phenylpropionaldehyde | ESI+ | 1.14 | 0.27 | 194.12 | − 3.40 | 0.00 | ||
4-Hydroxynonenal | ESI+ | 2.99 | 9.25 | 139.08 | − 1.88 | 0.02 | ||
7-Methylguanine | ESI+ | 1.45 | 1.54 | 83.54 | 0.48 | 0.03 | C02242 | |
Alpha-carboxyethyl hydroxychroman | ESI+ | 2.93 | 22.4 | 301.14 | − 1.43 | 0.00 | ||
Aminoethoxyacetic acid | ESI+ | 1.53 | 6.89 | 120.08 | − 2.06 | 0.00 | ||
Beta-alanine | ESI+ | 1.15 | 25.74 | 90.09 | − 1.36 | 0.03 | Pyrimidine metabolism | C00099 |
Deoxycholic acid 3-glucuronide | ESI+ | 3.28 | 10.34 | 569.31 | 0.08 | 0.03 | Pentose and glucuronate interconversions | C03033 |
Glycerophosphocholine | ESI+ | 2.12 | 1.76 | 280.10 | 0.735 | 0.01 | Glycerophospholipid metabolism | C00670 |
Hippuric acid | ESI+ | 1.65 | 1.52 | 90.52 | 0.70 | 0.01 | Phenylalanine metabolism | C01586 |
Isobutyryl-l-carnitine | ESI+ | 1.10 | 7.2 | 232.15 | − 2.26 | 0.04 | ||
l-Tryptophan | ESI+ | 1.63 | 12.56 | 205.13 | 0.66 | 0.00 | Glycine, serine and threonine metabolism | C00078 |
LysoPC(18:0)a | ESI+ | 2.41 | 23.63 | 524.37 | 0.39 | 0.00 | Glycerophospholipid metabolism | C04230 |
LysoPC(18:1(11Z))a | ESI+ | 2.92 | 21.39 | 544.34 | 0.81 | 0.01 | Glycerophospholipid metabolism | C04230 |
LysoPC(22:5(4Z,7Z,10Z,13Z,16Z))a | ESI+ | 1.14 | 20.3 | 592.34 | 0.69 | 0.01 | Glycerophospholipid metabolism | C04230 |
Phosphoribosyl pyrophosphate | ESI+ | 1.06 | 1.62 | 390.99 | − 1.74 | 0.00 | Pentose phosphate pathway | C00119 |
Phosphorylcholine | ESI+ | 2.23 | 8.19 | 207.11 | − 1.49 | 0.00 | Glycerophospholipid metabolism | C00588 |
Thromboxane B2 | ESI+ | 3.71 | 9.46 | 393.21 | 0.12 | 0.03 | C05963 | |
Trans-aconitic acid | ESI+ | 1.85 | 0.08 | 88.02 | 0.23 | 0.03 | C5-Branched dibasic acid metabolism | C02341 |
