Figure 5
Intrinsic disorder predisposition of RNA-directed RNA polymerase L (L). (A) The intrinsic disorder profile generated for L protein by a set of disorder predictors; PONDR VSL2, PONDR VL3, PONDR VLXT, PONDR FIT, IUPred2_long, and IUPred2_short are represented by black, red, blue, magenta, dark yellow-, and navy-colored straight lines respectively. A mean disorder profile calculated by averaging the outputs of seven predictors is represented by the green-colored short-dash line. Light green region around mean curve represents the error distribution for the mean. (B) MoRFs prediction by MoRFCHiBi_Web and ANCHOR server. Dashed cyan line (0.5) represents cut-off for ANCHOR and dashed blue line (0.725) represents cut-off for MCW server. (C) Modelled structure for L protein (residues 32–2092) using Swiss Model. Red colored regions are predicted to be disordered based on the calculated mean. The N- and C-terminals are shown with arrows in the structure.
