Figure 3
The heatmap of statistically significant and successfully annotated compounds represents the changes in metabolite levels in cortex and hippocampus of WT plus LPS (n = 11), APdE9 mice (n = 11), and APdE9 plus LPS (n = 9) groups versus WT control (n = 11). Heatmap of p values without correction, − log10 scaled: red—increased metabolites (fold-change > 0), blue—decreased metabolites (fold-change < 0). The statistical significance on the level of 0.05 after Bonferroni correction was calculated as a p value < 3.23 × 10−4. Details of the metabolites are provided in Supplementary Table S1 online.
