Figure 4
The heatmap of statistically significant and successfully annotated compounds represents the changes in the most affected lipid levels in the cortex and hippocampus of WT plus LPS (n = 11), APdE9 mice (n = 11), and APdE9 plus LPS (n = 9) groups versus WT control (n = 11). Heatmap of p values without correction − log10 scaled, red—increased lipids (fold-change > 0), blue—decreased lipids (fold-change < 0). The statistical significance after Bonferroni correction was considered as a p value < 3.48 × 10−5. Details of the metabolites are provided in Supplementary Table S2 online.
