Figure 2
From: Gene expression profiles during tissue remodeling following bladder outlet obstruction
Total gene expression patterns in the three experimental groups. (A) Gene expression profiles of urinary bladder tissues from the control, MH, and SH groups using RNA-seq results. Comparison analysis was performed between the SH versus control and MH versus control groups. In total, 1,813 genes exhibited more than twofold increases in mRNA expression in the MH and SH groups compared with the control group, whereas 507 genes were downregulated by at least 50% in the MH and SH groups. (B) RNA-seq-based GO analysis of genes upregulated more than twofold in the MH and SH groups compared with the control group (1,813 genes shown as dark pink in Fig. A). (C) Gene expression profiles with comparisons between the MH and SH groups and the MH and control groups. In total, 471 genes exhibited a more than twofold increase in mRNA expression in the MH group compared with the SH and control groups. Additionally, 214 genes showed a more than twofold decrease in expression in the MH group compared with the other two groups. (D) Expression pattern of each gene showing marked changes in mRNA expression in the MH group compared with the SH and control groups. The box represents the 25th to 75th percentile interval, and the line represents the median. The cross mark represents average. Top or bottom of bar extending from the box represents the maximum or minimum, respectively. *P < 0.05.
