Table 1 Patient characteristics and prevalence of CTCs.

From: Circulating tumour cells at baseline and late phase of treatment provide prognostic value in breast cancer

 

All patients (N = 110)

Baseline CTC negative (N = 55)

Baseline CTC positive (N = 55)

P value

Age

52.7 (23–84)

53.6 (34–84)

51.7 (23–79)

0.3545a

Histology

   

0.1482c

Ductal carcinoma in situ

11

3 (27.2%)

8 (72.8%)

 

Invasive ductal carcinoma

88

48 (54.5%)

40 (45.5%)

 

Other types

11

4 (36.4%)

7 (63.6%)

 

Intrinsic subtype

   

0.4874c

Luminal A-like

25

11 (44.0%)

14 (56.0%)

 

Luminal B-like (HER2 negative)

32

13 (40.6%)

19 (59.4%)

 

Luminal B-like (HER2 positive)

24

15 (62.5%)

9 (37.5%)

 

Erb-B2 overexpression

19

10 (52.6%)

9 (47.4%)

 

Basal-like

10

6 (60.0%)

4 (40.0%)

 

Stage

   

0.2702b

0

8

2 (25.0%)

6 (75.0%)

 

I

19

11 (57.9%)

8 (42.1%)

 

II

38

25 (65.8%)

13 (34.2%)

 

III

18

8 (44.4%)

10 (55.6%)

 

IV

20

6 (30.0%)

14 (70.0%)

 

N/A

7

   

Risk categories

   

0.4010b

Low risk

8

2 (25.0%)

6 (75.0%)

 

Intermediate risk

62

39 (62.9%)

23 (37.1%)

 

High risk

34

13 (38.2%)

21 (61.8%)

 

N/A

6

   

Tumour (TNM staging)

   

0.5570b

0

7

2 (28.6%)

5 (71.4%)

 

1

37

19 (51.4%)

18 (48.6%)

 

2

55

31 (56.4%)

24 (43.6%)

 

3

7

1 (14.3%)

6 (85.7%)

 

4

2

2 (100%)

0 (0%)

 

N/A

2

   

Node (TNM staging)

   

0.1483b

0

53

29 (54.7%)

24 (45.3%)

 

1

16

11 (68.7%)

5 (31.3%)

 

2

15

6 (40.0%)

9 (60.0%)

 

3

12

4 (33.3%)

8 (66.7%)

 

N/A

14

   

Metastasis (TNM staging)

   

0.0429c

0

89

49 (55.1%)

40 (44.9%)

 

1

20

6 (30.0%)

14 (70.0%)

 

N/A

1

   

ER

   

0.8352c

Negative

33

17 (51.5%)

16 (48.5%)

 

Positive

77

38 (49.4%)

39 (50.6%)

 

PR

   

0.8472c

Negative

63

31 (49.2%)

32 (50.8%)

 

Positive

47

24 (51.1%)

23 (48.9%)

 

Her-2

   

0.3286c

Negative

67

31 (46.3%)

36 (53.7%)

 

Positive

43

24 (55.8%)

19 (44.2%)

 

Ki67

   

0.5541c

 ≤ 20%

41

19 (46.3%)

22 (53.7%)

 

 > 20%

69

36 (52.2%)

33 (47.8%)

 
  1. aP value from Mann–Whitney test.
  2. bP value from Pearson’s chi-squared test for trend.
  3. cP value from Pearson’s chi-squared test.