Table 3 Cox univariate analysis and multivariate analysis of CTCs at the end-point follow-up visit.
PFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|
Cox univariate analysis | Cox multivariate analysis | Cox univariate analysis | Cox multivariate analysis | |||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
CTC at the end-point follow-up visit | 4.21 (1.77–9.99) | 0.001 | 3.51 (1.35–9.13) | 0.010 | 5.39 (1.52–19.11) | 0.009 | 3.02 (0.70–13.05) | 0.138 |
Intrinsic subtype | 1.30 (0.97–1.74) | 0.084 | 0.82 (0.44–1.51) | 0.517 | 1.30 (0.88–1.93) | 0.193 | 0.72 (0.26–1.94) | 0.511 |
Stage | 2.55 (1.70–3.83) | 0.000 | 1.52 (0.63–3.68) | 0.354 | 5.22 (2.53–10.78) | 0.000 | 3.38 (0.68–16.73) | 0.135 |
Risk categories | 4.65 (2.12–10.19) | 0.000 | 2.40 (0.49–11.60) | 0.278 | 28.78 (3.80–217.68) | 0.001 | 7.03 (0.37–133.32) | 0.194 |
Histology | 1.25 (0.52–3.00) | 0.615 | 2.09 (0.69–6.31) | 0.191 | 2.00 (0.66–5.99) | 0.218 | 10.48 (1.72–63.67) | 0.011 |
ER status | 0.50 (0.23–1.10) | 0.086 | 0.40 (0.08–1.86) | 0.240 | 0.46 (0.16–1.26) | 0.130 | 0.13 (0.01–1.51) | 0.104 |
PR status | 0.26 (0.10–0.69) | 0.007 | 0.27 (0.09–0.84) | 0.023 | 0.48 (0.15–1.51) | 0.208 | 0.41 (0.08–2.09) | 0.285 |
HER2 status | 1.12 (0.52–2.39) | 0.777 | 0.69 (0.26–1.80) | 0.444 | 1.16 (0.42–3.20) | 0.773 | 0.50 (0.10–2.51) | 0.399 |
Ki67 status | 2.06 (0.83–5.11) | 0.120 | 1.24 (0.40–3.82) | 0.709 | 3.71 (0.84–16.50) | 0.085 | 1.09 (0.18–6.64) | 0.926 |
Final model | 0.000 | 0.000 | ||||||
