Figure 1 | Scientific Reports

Figure 1

From: Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice

Figure 1

Gavage administration of GLAA promoted sleep in mice with pentobarbital-induced hypnosis. (a) GLAA did not affect the weight of mice. (b) GLAA did not alter the organ/body weight ratio of the spleen, liver, kidney or thymus. (c) GLAA promoted sleep by shortening sleep latency. (d) GLAA prolonged sleeping time. (e) GLAA increased the concentration of 5-HT in the hypothalamus (n = 4–5). (f) GLAA reduced the LPS content and raised the PG content in serum. The data are shown as the means ± SEMs; *p < 0.05, **p < 0.01, ***p < 0.001, and ‘ns’ indicates that the difference is not significant. The data are calculated from 10 samples per group, except specifically mentioned. And all the images are generated by GraphPad Prism 8. The animal experiment and the subsequent behavioural evaluation were performed twice. GLAA The acidic part of the alcohol extract of G. lucidum mycelia, 5-HT 5-hydroxytryptamine, LPS lipopolysaccharide, PG peptidoglycan.

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