Figure 1
Trajectories of changes in liver fat content according to initial changes in total BCAAs (panels A), Isoleucine (panels B), Leucine (panels C), and Valine (panels D). Data were adjusted for age, sex, total energy intake, protein intake, intervention group, HOMA-IR, BMI, liver fat content at the baseline, value for the each metabolites (total BCAAs, Isoleucine, Leucine, Valine) at the baseline, and changes in HOMA-IR and BMI form baseline to 6 months. The lowest tertile (T1) category indicates the largest reduction of circulating metabolites from the baseline to 6 months. Metabolite categories are defined as follow: total BCAAs level-T1, ≤ − 2.8 μg/mL; T2, − 2.8 to 4.7 μg/mL; T3, ≥ 4.7 μg/mL; Isoleucine level-T1, ≤ − 0.55 μg/mL; T2, − 0.55 to 0.88 μg/mL; T3, ≥ 0.88 μg/mL; Leucine level-T1, ≤ − 0.73 μg/mL; T2, − 0.73 to 1.86 μg/mL; T3, ≥ 1.86 μg/mL; Valine level-T1, ≤ − 1.77 μg/mL; T2, − 1.77 to 2.41 μg/mL; T3, ≥ 2.41 μg/mL.
