Table 1 Characteristics of the study population: women of childbearing age (Training set—Group 1).

Subjects n

25

186

72

114

Age (years), mean (range)

32.4 (20–39)

32.9 (20–43)

32.8 (23–41)

33.0 (20–43)

BMI (kg/m²) before pregnant, mean (range)

25.23 (19.72–36.81)

24.13 (16.23–42.32)

23.59 (16.65–38.67)

24.48 (16.23–42.32)

Social class

Managers-technicians/skilled/semiskilled-unskilled/unemployed, %

36.0/20.0/20.0/24.0

35.5/18.3/22.0/24.2

34.7/15.2/20.8/29.2

36.0/20.2/22.8/21.1

Educational level

Incomplete secondary or less/complete secondary/university %

28.0/12.0/60.0

19.3/25.3/55.4

25.0/27.8/47.2

15.8/23.7/60.5

Smoking during pregnancy, Yes/No n/n

2/23

30/156

9/63

21/93

Smoker, Yes/No n/n

3/22

30/156

8/64

22/92

Other atopic disorders, yes

25 (100%)^b

72 (39%)^a

72 (100%)

-

Allergic rhinitis, yes

23 (92%)^b,c

47 (25%)^a

47 (65%)^a

-

Atopic dermatitis, yes

8 (32%)^b

12 (6%)^a

12 (17%)

-

Allergic conjunctivitis, yes

17 (68%)^b

26 (14%)^a

26 (36%)

-

Food allergy, yes

5 (20%)^b

10 (5%)^a

10 (14%)

-

Drug allergy, yes

5 (20%)

14 (8%)

14 (19%)

-

Parental asthma, yes

6 (24%)^b,d

11 (6%)^a

6 (8%)

5 (4%)^a

Parental allergic rhinitis, yes

10 (40%)^b,d

36 (19%)^a

21 (29%)^d

15 (13%)^a,c

Parental atopic dermatitis, yes

3 (12%)

8 (4%)

2 (3%)

6 (5%)

Antibiotics consumption, yes

11 (44%)

57 (31%)

22 (31%)

35 (31%)

Paracetamol consumption, yes

18 (72%)

107 (56%)

39 (54%)

68 (60%)

Inhaled corticosteroids consumption, yes

2 (8%)

5 (3%)

3 (4%)

2 (2%)

Injectable corticosteroids consumption, yes

2 (8%)

7 (4%)

6 (8%)^d

1 (1%)^c

Blood leucocyte count /µl, mean (range)

9548 (6380–16,610)

9247 (5270–16,720)

9054 (5270–15,560)

9369 (5270–16,720)

Blood monocyte count /µl, mean (range)

590 (320–1080)

614 (240–1460)

618 (370–1160)

611 (240–1460)

Blood lymphocyte count /µl, mean (range)

1847 (1160–3130)

2017 (770–4290)

2021 (960–3600)

2015 (770–4290)

Blood basophil count /µl, mean (range)

32 (10–60)

31 (0–100)

28 (10–60)

32 (0–100)

Blood eosinophil count /µl, mean (range)

213 (70–350)^b,c,d

138 (0–500)^a

131 (0–380)^a

143 (0–500)^a

Blood neutrophil count /µl, mean (range)

6866 (3960–12,780)

6447 (3380–11,360)

6255 (3380–11,360)

6568 (3380–10,970)

Season at sampling

Winter/spring/summer/autumn %

24.0/20.0/20.0/36.0

25.3/10.8/22.0/41.9

38.9/11.1/19.4/30.6 ^d

16.7/10.5/23.7/49.1 ^c