Table 3 Treatment-dependency of post-treatment therapeutic effects.

From: Assessing the post-treatment therapeutic effect of pinaverium in irritable bowel syndrome: a randomized controlled trial

Treatment

Post-treatment

References

Follow-up duration

Date collected at

Did the therapeutic effects last?

Diet

 Low FODMAP diet

1 wk

wk 1

≥ 1 wk

29

Probiotics

 S. cerevisiae

3 wk

Every wk

1–2 wk

30

 L. plantarum

12 mo

mo 12

≥ 12 mo

31

Antibiotics

 Rifaximin

10 wka

Every wk

≥ 10 wk

13

10 wk

Every wk

≥ 10 wk

4

3 mo

Every wk

≥ 3 mo

32

Antispasmodics

 Phloroglucinol

1 wk

wk 1

≥ 1 wk

33

 Otilonium

10 wk

wk 3, 6, 10

≥ 10 wk

15

 pinaverium

57 wk

dy 1, 2, 3, wk 4, 9, 17, 25 ,33, 45, 57

between 9 and 17 wk

Current study

Peppermint oil

 Anise oil

2 wk

wk 2

≥ 2 wk

34

 Peppermint oil

4 wk

wk 4

≥ 4 wk

6

Antidepressants

 Fluoxetine

4 wk

wk 4

≥ 4 wk

7

 Paroxetine 20 mg, QD

1 yr

yr 1

< 1 yr (very low DCR)

8

Psychological therapies

 Cognitive behavior therapy

2 wk

wk 2

≥ 2 wk

10

 Mindfulness-based cognitive therapy

6 wk

wk 6

≥ 6 wk

35

 Cognitive-based tx

3 mo

mo 3

≥ 3 mo

36

 Cognitive-behavioral group therapy

3 mo

mo 3

≥ 3 mo

27

 Mindfulness-based stress and pain management

3 mo

After tx, mo 3

≥ 3 mo

37

 Relaxation response meditation

3 mo

wk 2, mo 3

≥ 3 mo

38

 Cognitive-behavioral internet therapy

3 mo

wk 6, mo 3

≥ 3 mo

39

 Cognitive behavioral therapy

3 mo

wk 1, 2, 3, mo 3

≥ 3 mo

40

 Telephone/web CBT

4 mo

mo 4

≥ 4 mo

11

 Behavioral treatment

5 mo

mo 5

≥ 5 mo

41

 Cognitive behavioral therapy

6 mo

mo 2, 3, 6

≥ 6 mo

42

 Mindfulness-based stress reduction

6 mo

mo 6

< 6 mo (low DCR)

28

 Psychodynamic inter-personal therapy

1 yr

yr 1

< 1 yr (very low DCR)

8

 Hypnotherapy

1 yr

mo 3, yr 1

≥ 1 yr

43

 Comprehensive self-management

1 yr

mo 3, 6, 12

≥ 1 yr

11

 Comp CBT: 8 wkly 1 h

 Brief CBT: one 90 min

12 mo

wk 9, mo 6, 12

≥ 1 yr

9

5-HT3 antagonist

 Alosetron, 1 mg, BID

2 wk

Every wk

< 1 wk

44

4 wk

Every wk

< 1 wk

45,46,47

1 mo

mo 1

< 1 mo

48

  1. Regular font: The trials reviewed by Ford et al.5. Italic font: updated studies not reviewed by the American College of Gastroenterology.
  2. CBT cognitive behavior therapy, Comp comprehensive, DCR data collection resolution; dy day(s), FODMAP fermentable oligosaccharides, disaccharides, monosaccharides, and polyols; mo month(s), QD every day, yr year.
  3. aRepeated treatment design: 2 wk of first rifaximin treatment + 10 wk follow-up + 2 wk of second rifaximin treatment + 4 wk follow-up. Data from the first treatment and the first follow-up were used here.
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