Figure 2
Increased myeloid cell signatures and decreased non-hematopoietic cell signatures characterize the majority of lupus patients. (a) Hedges’ g effect sizes of immune and non-hematopoietic cell signatures in DLE, class III/IV LN GL, and class III/IV LN TI as compared to tissue CTLs. Significant p-values reflect significant differences in enrichment of the immune cell signatures or non-hematopoietic cell signatures in lupus tissues as compared to CTL as determined by Welch’s t-test with Bonferroni correction (Supplemental Fig. S1). (b) R2 values derived from linear regression of the monocyte-derived macrophage or the tissue-resident macrophage markers with the monocyte/MC GSVA scores in individual patients and CTLs from lupus-affected tissues (Supplemental Fig. S3). Significant p-values reflect significantly non-zero slopes. (c) Pearson correlation coefficients between tissue-resident macrophage markers in LN. For all calculations, the following sample numbers were used: DLE [CTL (n = 8), DLE (n = 9)], LN GL [CTL (n = 14), Cl 3/4 (n = 22)], and LN TI [CTL (n = 15), Cl 3/4 (n = 22)]. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.
