Figure 2 | Scientific Reports

Figure 2

From: Time course profiling of host cell response to herpesvirus infection using nanopore and synthetic long-read transcriptome sequencing

Figure 2

The effect of viral infection on the transcript isoforms of host cells. (a) A total of 546 transcript isoforms were detected with at least ten reads in the datasets of transcripts derived from infected bovine cells compared to the transcripts present in the mock dataset. (b) Gray rectangles represent previously detected transcript isoforms. The blue rectangles represent a novel non-spliced and two new splice variants of the FOS transcript. Introns are represented by lines between rectangles. The intron which is responsible for the increased degradation rate of FOS is shown in red. Orange rectangles represent the ORF. (c) The blue rectangles represent the novel TES isoform of SOD1, the lines represent introns, and orange rectangles illustrate the ORF. A SOD1 isoform with an upstream TES detected during the infection but not in the mock samples. Panel (a) was created using R v. 3.6.3 (https://www.r-project.org/). Panel (b) and (c) was created using IGV (https://software.broadinstitute.org/software/igv/). The figure was created using Inkscape v. 0.92 (https://inkscape.org/).

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