Figure 2 | Scientific Reports

Figure 2

From: Repeat and single dose administration of gadodiamide to rats to investigate concentration and location of gadolinium and the cell ultrastructure

Figure 2

Gadolinium distribution in the rat brain after a cumulative gadodiamide dose. Gadolinium distribution is consistent over a 1-year period following a cumulative dose of 12 mmol/kg over 5 weeks (n = 3 per group), with the highest concentration in the DCN. Localization of gadolinium across the brain measured by LA-ICP-MS. (a) representative images from each brain level and each treatment group on a common scale—the highest concentration of gadolinium is observed in the DCN in level 3 (arrow, bottom row). (b) The same images with each level exhibited on a different scale to highlight areas of gadolinium in each. (c) Example H&E images of the same levels with major features marked (levels are defined as (1) cerebrum at the optic chiasm, (2) cerebrum at the base of the posterior hypothalamus (3) mid-cerebellum and medulla oblongata). Ac anterior commissure, Cc cerebral cortex, Cca corpus callosum, DCN deep cerebellar nuclei, Hc hippocampus, H hypothalamus, Mo medulla oblongata, Sr striatum, T thalamus.

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