Table 1 Co-localization of autosomal sDMRs with BCL6, AR, or ESR1-enriched regions.

From: Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver

 

Sex-phenotype dependent sDMRs

Female liver

Male liver

Co-localized with BCL6-ChIP enriched regions** (% sDMRs)

Co-localized with ESR1-ChIP enriched regions*** (% sDMRs)

Co-localized with BCL6-ChIP enriched regions** (% sDMRs)

Co-localized with AR-ChIP enriched regions**** (% sDMRs)

Direct Overlap

Within 10 kb

Direct Overlap

10 kb

Direct Overlap

10 kb

Direct Overlap

10 kb

Female-biased sDMRs

433

12 (2.8)*

133 (30.7)*

26 (6.0)*

153 (35.3)*

4 (0.9)

100 (23.1)*

1 (0.2)

46 (10.6)*

Male-biased sDMRs

3414

81 (2.4)*

932 (27.3)*

255 (7.5)*

1449 (42.4)*

413 (12.1)*

1573 (46.1)*

87 (2.5)*

721 (21.1)*

Total sDMRs

3847

103 (2.7)

1065 (27.7)

295 (7.7)

1602 (41.6)

477 (12.4)

1673 (43.5)

97 (2.5)

767 (19.9)

Total number of autosomal ChIP peaks

n/a

22,851

31,235

20,994

7850

  1. *Statistical significance of co-localization of female-biased or male-biased sDMRs with TF-enrichment was determined by comparing the co-localization of 500 permutations with ChIP peaks. Asterisks indicate statistically significant results.
  2. **BCL6-ChIP peaks in female and male livers extracted from GSE31578- GSM784032, GSM784028 replicates 3 and 2, respectively; ***ESR1-ChIP peaks in female liver extracted from GSE32244; ****AR-ChIP peaks in male liver extracted from GSE32244.
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