Figure 3 | Scientific Reports

Figure 3

From: A comprehensive transcriptomic landscape of cholangiocarcinoma based on bioinformatics analysis from large cohort of patients

Figure 3

Network construction and module detection. (a) Functional enrichment analysis of DEGs by KEGG. The y-axis represents KEGG-enriched terms. The x-axis indicates the fold of enrichment. The size of each dot indicates the number of genes under a specific term. The color of the dots represents the adjusted p value. (b) Clustering dendrogram of genes with dissimilarity based on the topological overlap, together with assigned module colors using WGCNA analysis. (c) Illustration of association between modules and traits in WGCNA. Each row refers to a module eigengene, column to a trait. Module ‘turquoise’ is highlighted with black rectangle with the highest association coefficient. (d) PPI network of the DEGs within the selected module. The nodes represent each gene with edges mean the interactions. Purple and red means gene upregulation and downregulation, respectively.

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