Figure 10

source of prorenin in diabetes. Prorenin released to the lumen, binds PRR, thus leading to its activation and stimulation of MAPK/ERK1/2 intracellular pathway which is known to induce profibrotic factors in these cells. Upregulation of PRR is mediated by high glucose, but not osmolality. In this scenario, it is likely that GLUT-1 and GLUT-12 transporters contribute to the HG-dependent PRR trafficking through mechanisms including glycolysis and metabolic intermediaries such as succinate and alpha-ketoglutarate through their receptors.
Working hypothesis representing the potential effects of high glucose on PRR cellular preferential distribution to the plasma membrane. In the collecting duct, the principal cell is the main