Table 2 Integration of global gene expression with allele-specific expression of imprinted genes in Zfp57-/- day 12-JB1 cells.
Domain | Chromosome | ICR methylation | Gene | Allelic expression wild-type NPCs | Allelic expression Zfp57-/- NPCs | Global expression change |
|---|---|---|---|---|---|---|
Gpr1 | chr1 | Maternal | Zdbf2 | Paternal | Biallelic | Up-regulated |
Adam23 | Biallelic | Biallelic | Up-regulated | |||
Nnat | chr2 | Maternal | Nnat | Paternal | Biallelic | Unchanged |
Blcap | Biallelic | Biallelic | Down-regulated | |||
Gnas | chr2 | Maternal | Nespas | Paternal | Biallelic | Up-regulated |
Peg10 | chr6 | Maternal | Sgce | Paternal | Biallelic | Unchanged |
Peg10 | Paternal | Biallelic | Up-regulated | |||
Asb4 | Maternal | Biallelic | Unchanged | |||
Mest | chr6 | Maternal | Mest | Paternal | Biallelic | Up-regulated |
Peg3 | chr7 | Maternal | Zim1 | Maternal | All. bias reduced | Down-regulated |
Peg3 | Paternal | Biallelic | Up-regulated | |||
Usp29 | Paternal | Biallelic | Unchanged | |||
Snrpn | chr7 | Maternal | Snhg14 | Paternal | Biallelic | Unchanged |
Snrpn | Paternal | Biallelic | Up-regulated | |||
A230057D06Rik | Paternal | Biallelic | Down-regulated | |||
Ndn | Paternal | Biallelic | Unchanged | |||
Magel2 | Paternal | Biallelic | Unchanged | |||
Mkrn3 | Paternal | Biallelic | Down-regulated | |||
Peg12 | Paternal | Biallelic | Down-regulated | |||
H19 | chr7 | Paternal | H19 | Maternal | Biallelic | Up-regulated |
Igf2 | Paternal | All. bias reduced | Down-regulated | |||
Igf2os | Paternal | Uncertain | Down-regulated | |||
Kcnq1ot1 | chr7 | Maternal | Th | Maternal | Biallelic | Down-regulated |
Kcnq1ot1 | Paternal | Biallelic | Unchanged | |||
Cdkn1c | Maternal | Biallelic | Down-regulated | |||
Plagl1 | chr10 | Maternal | Plagl1 | Paternal | Biallelic | Down-regulated |
Phactr2 | Maternal | Biallelic | Unchanged | |||
Grb10 | chr11 | Maternal | Grb10 | Maternal | Biallelic | Down-regulated |
Ddc | Paternala | All. bias inverted | Up-regulated | |||
Commd1 | chr11 | Maternal | Zrsr1 | Paternal | Biallelic | Up-regulated |
Meg3 | chr12 | Paternal | Dlk1 | Paternal | Biallelic | Down-regulated |
Meg3 | Maternal | Biallelic | Unchanged | |||
Rian | Maternal | Biallelic | Up-regulated | |||
Mirg | Maternal | Biallelic | Up-regulated | |||
Trappc9 | chr15 | Maternal | Kcnk9 | Pref. maternala | Biallelic | Down-regulated |
Peg13 | Paternal | Biallelic | Unchanged | |||
Trappc9 | Biallelic | Biallelic | Down-regulated | |||
Igf2r | chr17 | Maternal | Igf2r | Pref. maternala | All. bias inverted | Down-regulated |
Airn | Paternala | Biallelic | Up-regulated | |||
Impact | chr18 | Maternal | Impact | Paternal | Biallelic | Up-regulated |
