Figure 1

Multimodal imaging of eyes at the previtelliform, vitelliform, pseudohypopyon, and vitelliruptive stages. At the previtelliform stage, spectral-domain optical coherence tomography (SD-OCT) images revealed intact retinal layers (A). Short-wavelength fundus autofluorescence (SW-AF) images demonstrated macular hypoautofluorescence (hypoAF) while images of the choriocapillaris (CC) by optical coherence tomography angiography (OCTA) demonstrated a homogenous pattern, both as observed in healthy eyes (B,C). At the vitelliform stage, a hyperreflective material (red asterisk) is observed in SD-OCT images (D). This material is hyperautofluorescent (hyperAF) in SW-AF images (E) and obstructs the OCTA signal, causing the area to appear as dark and devoid of CC (F). The eyes at the pseudohypopyon stage presented with hyporeflective subretinal fluid and a thickened interdigitation zone (IZ) band with abnormal reflectance (green arrow) in SD-OCT images (G). On SW-AF images, patchy hypoAF was observed in the macula, with inferior displacement of the hyperAF material (H). The CC corresponding to the lesion area appeared heterogeneous, with regions where the CC was visible and regions where it was not (I). Eyes at the vitelliruptive stage also presented with hyporeflective fluid on SD-OCT images, but the IZ band appeared as fragmented, with the remaining outer segments appearing in clumps (orange arrow) (J). SW-AF images revealed macular hypoAF, whereas the CC appeared granular and bright on OCTA images (K,L). The yellow dashed lines on the SD-OCT images represent the approximate location of the CC slab.