Figure 2

Multimodal imaging of eyes at the atrophic stage. Spectral-domain optical coherence tomography (SD-OCT) images revealed two different presentations of the atrophic stage. One presentation involves shallow, hyporeflective fluid, with loss of the interdigitation zone (IZ) band (green arrow) (A,D). The other presentation involves loss of outer retinal layers with subsequent collapse of the inner retinal layers (G,J,M). All of these lesions in SD-OCT images presented with increased signal transmission into the choroid. In short-wavelength fundus autofluorescence (SW-AF) images (B,E,H,K,N), these lesions corresponded to hypoautofluorescent (hypoAF) areas, with denser hypoAF observed in patients with collapse of the inner retinal layers on SD-OCT images (H,K,N). In OCTA images, the aforementioned lesions on SD-OCT and SW-AF imaging appeared as areas of bright choriocapillaris (CC), with varying degrees of atrophy. In the eyes with hyporeflective fluid, CC atrophy was patchy (C,F), whereas in the patients with collapse of the inner retinal layers, CC atrophy was more severe, with the underlying choroidal vessels visible (I,L,O). The yellow dashed lines on the SD-OCT images represent the approximate location of the CC slab.