Figure 2
An illustrative example of how network structure influences the competitive impact results between driver gene and drug. A disease network with 12 genes and 19 interactions is given. Node 1 (red) is a driver gene whose state is fixed by 1. Node 0 (green) is a drug whose state is fixed by −1. An undirected interaction is temporarily added between the drug and each normal gene for computing support of the normal gene to the driver gene against impact from the drug. The state of each gene converges to a steady value which is a convex combination of the competitors’ states, and does not depend on the initial states of genes. The color gradient represents support bias to two competitors. (A) The weights are kept at the default value of 1 for all links. The result shows that most genes in the network impacted by the driver gene, except 10 and 11 (B) A handful of links are changed in weight. Interestingly, there are large fluctuations in the network. Most genes in the network turn to impacted by the drug.
