Figure 4
Overview of metabolic pathway changes resulting from exposure to 60Co γ-radiation. (A) Venn diagram summarizing dysregulated metabolic pathways from the three cohorts. (B) Venn diagram summarizing the metabolic pathways from cohort 3 (mice) that were dysregulated with or without amifostine treatment (200 mg/kg). (C) Representative metabolite trajectories from the LC–MS (triangles) and NMR (circles) data sets within cohort 1 or 2. *Denotes p-values < 0.05 and VIP > 1. (D) Representative metabolite trajectories from the LC–MS (triangles) and NMR (circles) data sets within cohort 3: radiation exposure (RAD D1 vs D5, gray) and radiation exposure with amifostine pretreatment (RAD+200 D5 vs D9, dark blue). *Denotes p-values < 0.05 and VIP > 1.
