Figure 4
Long-term adipose tissue loss did not affect structural bone parameters. (a) Total areal bone mineral density (aBMD) measured by DXA at 0, 1, and 2 weeks after dimerizer injection. (b) Trabecular volumetric BMD (vBMD) of tibia, (c) cortical thickness of tibia, (d) trabecular vBMD of femur, and (e) cortical thickness of femur measured by pQCT 6 weeks after dimerizer injection. (f) Trabecular bone volume fraction (BV/TV), (g) trabecular thickness (Tb.Th), (h) trabecular number (Tb.N), (i) trabecular separation (Tb.Sp) of vertebra L5 measured by μCT 6 weeks after dimerizer injection. (a) Data are arithmetic mean ± sem. (b–i) Symbols in the scatter plots represent individual mice and the bars indicate arithmetic mean. dim, dimerizer; veh, vehicle. n = 12 veh and 12 dim mice (except for b where n = 11 dim mice due to laboratory error). (a–i) Student’s t-test.
