Table 1 Top 40 differentially expressed coding genes between NAT and Na.

From: Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma

Gene IDb

Gene name

P valuec

Fold change (NAT/N)

DEGs of NAT/LT− vs Nd

ENSG00000213977.7

TAX1BP3

2.43E−12

3.67

Yese

ENSG00000147586.9

MRPS28

4.97E−11

2.39

Yes

ENSG00000257727.5

CNPY2

1.34E−08

2.21

Yes

ENSG00000148180.18

GSN

2.1E−08

3.82

Yes

ENSG00000174903.15

RAB1B

4.09E−08

−1.59

Yes

ENSG00000203791.14

METTL10

4.15E−08

1.93

Yes

ENSG00000170296.9

GABARAP

8.02E−08

4.17

Yes

ENSG00000143368.9

SF3B4

7.59E−07

−1.56

Yes

ENSG00000136371.10

MTHFS

2.29E−06

2.42

Yes

ENSG00000171295.12

ZNF440

2.73E−06

1.53

Noe

ENSG00000088038.17

CNOT3

4.31E−06

−2.16

Yes

ENSG00000132471.11

WBP2

6.74E−06

−1.62

Yes

ENSG00000277203.1

F8A1

8.99E−06

−1.75

Yes

ENSG00000183889.12

AC138969.4

1.44E−05

−1.84

Yes

ENSG00000198171.12

DDRGK1

1.87E−05

−1.54

Yes

ENSG00000128739.21

SNRPN

2.59E−05

2.29

Yes

ENSG00000104969.9

SGTA

2.76E−05

−1.51

Yes

ENSG00000263290.5

SCAMP3

3.07E−05

−1.58

Yes

ENSG00000164039.14

BDH2

3.16E−05

1.71

Yes

ENSG00000147955.16

SIGMAR1

3.26E−05

−1.56

Yes

ENSG00000175274.18

TP53I11

5.42E−05

−1.74

Yes

ENSG00000270011.6

ZNF559-ZNF177

5.71E−05

2.80

Yes

ENSG00000205544.3

TMEM256

6.32E−05

3.71

Yes

ENSG00000111775.2

COX6A1

6.36E−05

2.28

Yes

ENSG00000100350.14

FOXRED2

6.66E−05

−1.87

Yes

ENSG00000279576.1

AP000769.1

8.82E−05

16.16

Yes

ENSG00000181264.8

TMEM136

9.61E−05

1.54

Yes

ENSG00000115239.21

ASB3

9.75E−05

1.69

Yes

ENSG00000100348.9

TXN2

0.000123

−1.57

Yes

ENSG00000167182.13

SP2

0.000132

−1.82

Yes

ENSG00000277462.1

ZNF670

0.000133

2.05

Yes

ENSG00000167644.11

C19orf33

0.000162

19.70

Yes

ENSG00000134590.13

FAM127A

0.000174

−1.62

Yes

ENSG00000239697.10

TNFSF12

0.000177

−1.83

Yes

ENSG00000164898.12

C7orf55

0.000191

3.25

Yes

ENSG00000124614.13

RPS10

0.000237

13.41

Yes

ENSG00000188257.10

PLA2G2A

0.000277

−14.64

Yes

ENSG00000196757.7

ZNF700

0.000284

1.59

Yes

ENSG00000116649.9

SRM

0.000299

−1.83

Yes

ENSG00000189171.14

S100A13

0.000328

1.93

Yes

  1. aNAT, normal appearing tumor adjacent tissue; N, normal thyroid control.
  2. bThe human genome GRC38 was used for gene mapping and annotation.
  3. cBenjamini and Hochberg multiple testing corrected p-value. Model was adjusted for age, gender and LT status.
  4. dNAT/LT−, normal appearing thyroid tissue without co-existance of lymphocytic thyroiditis.
  5. eYes, the gene is overlapping with the DEGs of NAT/LT− vs N; No, no overlapping.
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