Figure 1
From: Attenuated asthma phenotype in mice with a fetal-like antigen receptor repertoire
Serum immunoglobulin levels. In serum of wt and TdT−/− mice, both sensitized and non-sensitized, immunoglobulin levels of (a) total IgG1, (b) total IgE, (c) OVA-specific IgG1 and (d) OVA-specific IgE were measured using ELISA. Sensitization induced a significant rise in OVA-specific IgG1 and IgE levels. No significant differences between wt and TdT−/− mice were observed in OVA-specific IgE levels. Total IgE and total IgG1 levels were significantly increased after sensitization for both strains. The increase in IgG1 levels was significantly higher and the increase in IgE levels was significantly lower in TdT−/− mice when compared to wt (mean shown as blue lines, SEM shown as black bars).
