Figure 3
From: Attenuated asthma phenotype in mice with a fetal-like antigen receptor repertoire
Content of eosinophils in bronchoalveolar lavage (BAL) fluids. In BAL fluids of wt and TdT−/− mice, both sensitized and non-sensitized, content of eosinophils were measured using a pulse area counter. No eosinophils were detectable in the BAL fluids of non-sensitized animals. This applies to both genotypes, wt and TdT−/−. Sensitization and aerosolic challenge with OVA caused a significant influx of eosinophils (wt p < 0.001 and TdT−/− p < 0.0001) in both genotypes. However, this influx was markly reduced in TdT−/− mice compared to wt mice (p = 0.06; mean shown as blue lines, SEM shown as black bars).
