Table 1 Fold difference in kidney RAS gene expression between Lewis and Lewis Polycystic Kidney (LPK) rats at 10 weeks of age.

From: Renal denervation does not affect hypertension or the renin-angiotensin system in a rodent model of juvenile-onset polycystic kidney disease: clinical implications

Gene

ΔΔCt (Lewis)

ΔΔCt (LPK)

Fold difference v. Lewis (range)

P value

Renin

0.0 ± 0.4

1.5 ± 0.2

0.34 (0.29–0.40)

0.014

AGT

0.0 ± 0.6

3.2 ± 0.3

0.11 (0.09–0.14)

< 0.001

ACE1

0.0 ± 0.3

-1.6 ± 0.2

3.08 (2.73–3.47)

< 0.001

ACE2

0.0 ± 0.2

4.0 ± 0.3

0.06 (0.05–0.08)

< 0.001

Agtr1a

0.0 ± 0.1

0.7 ± 0.2

0.61 (0.52–0.72)

0.013

  1. RAS renin-angiotensin system, AGT angiotensinogen, ACE angiotensin-converting enzyme, Agtr1a angiotensin type 1a receptor. Data are presented as ΔΔCt with the Lewis animals used as the reference group. Fold difference (range) was calculated using the 2−(ΔΔCt ± Standard Error (SE) of the ΔCt) method.
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