Table 3 Fold difference in kidney RAS gene expression in Lewis Polycystic Kidney (LPK) rats after RDN.

From: Renal denervation does not affect hypertension or the renin-angiotensin system in a rodent model of juvenile-onset polycystic kidney disease: clinical implications

Gene

ΔΔCt

Fold difference vs. sham (range)

P value

Sham RDN

Total RDN

Afferent RDN

Total RDN

Afferent RDN

Renin

0.0 ± 0.2

− 0.3 ± 0.2

− 0.3 ± 0.5

1.27 (1.10–1.46)

1.19 (0.81–1.75)

0.84

AGT

0.0 ± 0.6

0.6 ± 0.4

− 1.0 ± 0.5

0.67 (0.51–0.87)

2.07 (1.49–2.87)

0.10

ACE1

0.0 ± 0.1

0.2 ± 0.2

0.4 ± 0.4

0.87 (0.75–1.02)

0.74 (0.56–0.99)

0.64

ACE2

0.0 ± 0.4

− 0.1 ± 0.2

− 1.0 ± 0.5

1.07 (0.95–1.20)

2.00 (1.43–2.82)

0.20

Agtr1a

0.0 ± 0.3

− 1.0 ± 0.4

− 0.3 ± 0.5

1.98 (1.47–2.65)

1.22 (0.89–1.68)

0.25

  1. RAS renin-angiotensin system, AGT angiotensinogen, ACE angiotensin-converting enzyme, Agtr1a angiotensin type 1a receptor. Data are presented as ΔΔCt with the sham animals used as the reference group. Fold difference (range) was calculated using the 2−(ΔΔCt ± Standard Error (SE) of the ΔCt) method.
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