Table 4 Morphometric and biochemical parameters at 10 weeks of age.

From: Renal denervation does not affect hypertension or the renin-angiotensin system in a rodent model of juvenile-onset polycystic kidney disease: clinical implications

 

Sham RDN

Total RDN

Afferent RDN

Treatment effect

Lewis (n)

(5)

(4)

(4)

 

KW/BW ratio (%)

0.8 ± 0.02

0.8 ± 0.04

0.8 ± 0.01

0.88, 0.43

Heart weights (g)

0.79 ± 0.07

0.82 ± 0.08

0.92 ± 0.11

1.6, 0.23

HW/BW ratio (%)

0.33 ± 0.01

0.33 ± 0.01

0.35 ± 0.02

2.3, 0.12

24 h water intake (ml)

18.2 ± 4.1

21.2 ± 2.6

23.8 ± 2.3

0.03, 0.97

24 h urine output (ml)

8.5 ± 1.7

10.2 ± 0.9

10.4 ± 1.8

0.14, 0.87

UPC

0.2 ± 0.0

(0.19/0.13)#

(0.07/0.39)#

n/a, n/a

CCR (ml/min)

2.8 ± 0.6

2.1 ± 0.3

2.3 ± 0.5

0.22, 0.80

Plasma urea (mmol/L)

7.0 ± 0.5

8.3 ± 1.0

7.3 ± 0.4

0.72, 0.50

Plasma creatinine (µmol/L)

24.2 ± 1.9

38.5 ± 10.4

27.5 ± 2.5

0.29, 0.75

24 h urine sodium (mmol)

1.6 ± 0.5

2.3 ± 0.2

1.6 ± 0.2

2.11, 0.15

LPK (n)

(3–4)

(4)

(3–5)

 

KW/BW ratio (%)

8.3 ± 0.5

7.4 ± 0.7

8.8 ± 0.8

0.88, 0.43

Heart weights (g)

0.98 ± 0.06

0.90 ± 0.07

1.05 ± 0.05

1.6, 0.23

HW/BW ratio (%)

0.54 ± 0.03

0.46 ± 0.05

0.57 ± 0.04

2.3, 0.12

24 h water intake (ml)

40.5 ± 1.0

39.1 ± 3.4

35.8 ± 4.6

0.03, 0.97

24 h urine output (ml)

27.4 ± 1.7

26.6 ± 2.8

23.6 ± 5.2

0.14, 0.87

UPC

5.2 ± 1.5

2.7 ± 0.4

8.6 ± 6.7

n/a, n/a

CCR (ml/min)

1.2 ± 0.4

1.6 ± 0.3

1.0 ± 0.3

0.22, 0.80

Plasma urea (mmol/L)

26.5 ± 8.6

15.6 ± 0.7

24.1 ± 6.5

0.72, 0.50

Plasma creatinine (µmol/L)

65.7 ± 33.2

32.5 ± 4.1

71.0 ± 30.2

0.29, 0.75

24 h urine sodium (mmol)

1.4 ± 0.2

1.7 ± 0.1

1.3 ± 0.1

2.11, 0.15

  1. RDN, renal denervation. KW/BW, kidney weight/body weight. HW/BW, heart weight/body weight. UPC, urine protein to creatinine ratio. CCR, creatinine clearance rate. Data is expressed as the mean ± SEM. #In the Lewis, 2 animals in the total RDN and 2 animals in the afferent RDN group had urine protein levels below the level of detection. Thus the values for UPC are provided as each animals individual result and no statistical analysis was undertaken. Treatment effect is provided as F statistic and P value, indicating overall treatment effect determined using two-way ANOVA with strain and treatment as the two variables.
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