Figure 3 | Scientific Reports

Figure 3

From: Characterization of microglial transcriptomes in the brain and spinal cord of mice in early and late experimental autoimmune encephalomyelitis using a RiboTag strategy

Figure 3

Changes in pre-onset stage of the disease. (A) Canonical Pathways from IPA. Bars correspond to the top 16 Canonical Pathways that surpassed the Ingenuity statistical threshold using the Benjamini–Hochberg multiple testing correction of Fisher’s Exact Test in both brain and spinal cord of pre-onset animals. (B) Upstream analysis in IPA identified TNF as a master regulator of 169 differentially expressed genes in the experiment and it exerts its effects through 12 intermediary genes. These relationships are depicted in the schematic. The graph and the network were generated through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis).

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