Figure 1
From: Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
Effects of Apelin on tumor volume and weight. (A) Tumor volume curves and tumor weight of MC38 cancer cells subcutaneously (s.c.) inoculated into WT or Apelin-KO mice (n = 7 for each group). (B) Tumor growth curves and tumor weight of LLC cells s.c. inoculated into WT or Apelin-KO mice (n = 6 for each group). (C) Schedule of tumor models using ALZET osmotic pumps to infuse [Pyr1]Apelin-13 or saline, and MC38 tumor growth curves (n = 5 for each group). MC38 tumor weights on day 19 after inoculation were calculated (n = 5 for each group). All experiments were repeated at least twice. The error bars indicate mean ± SD and all data were analyzed by two-sided Student's t-test. *p < 0.05.
